Prevalence of hepatitis B virus precore stop codon mutations in chronically infected children
نویسندگان
چکیده
منابع مشابه
Precore Codon 28 Stop Mutation in Hepatitis B Virus from Patients with Hepatocellular Carcinoma
OBJECTIVES Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis. METHODS A total of 73 patients with HBV-related hepatocellular carcinoma were included in this study. Polymerase chain reaction (PCR) was performed in DNA samples extracted from 73 sera to ampli...
متن کاملMutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
ABSTRACT Background and objectives: Globally, about one third of the population has been infected with Hepatitis B virus (HBV) and more than 400 million people have become chronically infected. Nearly, 20-25% of all carriers develop serious liver diseases such as cirrhosis, chronic hepatitis and hepatocellular carcinoma (HCC). According to t...
متن کاملPrecore and Core Promoter Mutations of the Hepatitis B Virus Gene in Chronic Genotype C -Infected Children
The precore (G1896A) and core promoter (A1762T, G1764A) mutations of the hepatitis B virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults. We analyzed these mutations in chronically HBV-infected children. Serum was collected from 37 children with chronic HBV infection from March 2005 to September 2008. HBV DNA extracti...
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Although Korea is one of the endemic areas of hepatitis B virus (HBV) infection, the prevalence of naturally occurring variants in the major hydrophilic region (MHR) of the surface (S) gene of HBV has not been determined. In the present study, the prevalence of these variants was examined in terms of the clinical state, and HBeAg serostatus in a large series of Korean patients with chronic HBV ...
متن کاملHepatitis B Virus Carrying Drug - resistance Compensatory Mutations in Chronically Infected Treatment - naive Patients
Objective: The prevalence of hepatitis B virus (HBV) is highly variable throughout the world. Geographical regions are classified according to the prevalence of hepatitis B surface antigen in the general population as high (>8%), moderate (2-7%), and low endemicity (<2%). Turkey has a moderate endemicity level of HBV infection which is a serious health problem. Currently, there are various nucl...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2006
ISSN: 1007-9327
DOI: 10.3748/wjg.v12.i14.2235